A comprehensive test to detect sensitivity to multiple peptides in cow’s milk dairy
Delayed sensitivities to peptides in dairy can present up to 72 hours after consuming dairy foods. These sensitivities are based on IgG or IgA antibody-driven reactions and can affect both the local intestinal environment with acute symptoms, as well as the extra-intestinal systems from the skin, to the joints, brain, and other internal organs and tissue systems.
Detecting sensitivity to cow’s milk can be difficult due to its ubiquitous presence in the Western diet, symptom overlap with other common conditions, and the often delayed nature of sensitivity symptoms.
Vibrant has developed the Dairy Zoomer to answer the need for a comprehensive peptide-level test to detect with the highest sensitivity and specificity whether an individual is sensitive to any of the multiple peptides found in cow’s milk.
The Dairy Zoomer will also aid healthcare providers in determining if cow’s milk dairy may be at the root of an individual’s symptoms or medical conditions, and guide nutritional interventions based on specific lab results.
Only healthcare providers licensed in their state may order laboratory testing.
- αS1-casein & αS2-casein
- Beta-casomorphin (BCM 7)
- α -Lactalbumin
- ß – Lactoglobulin
- Serum albumin
Allergy test in this Zoomer is only available through serum and not available with Dried blood spot.
If you have the following symptoms, you may be a good candidate for the Dairy Zoomer:
- Abdominal pain during or after meals
- Colic(in infants)
- Eczema or other rashes
- Mucous-filled cough
- Runny nose
- Eye irritation
- Recurring ear infections
- Other food sensitivities and allergies
- Atopic dermatitis
- Family history of dairy allergy
- Advanced age
Can the Vibrant Wellness Dairy Zoomer differentiate if a person can consume A1 vs. A2 milk?
Beta-casein (β-casein) is a 209 amino acid subunit of casein milk protein. The difference between the A1 and the A2 type β-casein variants is a single amino acid substitution at the 67th residue of the protein chain.
Thus, the ONLY difference in A1 and A2 variants is the amino acid at position 67.
A1 has histidine at position 67 whereas A2 has proline at position 67. Histidine does not bind as well as the amino acids positioned on either side of the chain and is more prone to cleavage during human digestion.
When A1 β-casein is metabolized, Beta casomorphin 7(BCM7/BCM), a peptide consisting of 7 amino acids with opioid properties, can break off; the immune system can potentially develop antibodies to this peptide independently.
Thus, if a person is ONLY producing antibodies to BCM7 (and does not react specifically to beta-casein) we can say this is a sensitivity specifically to A1 β-casein and not A2 β-casein.
If an individual shows an antibody response to β-casein only, we cannot differentiate if the sensitivity is to A1 vs. A2 casein. It is recommended to avoid all cow milk casein protein with this pattern of reactivity.
If someone is reactive (has elevated antibodies) on the Vibrant Wellness Dairy Zoomer, is it safe for them to consume other mammalian milks (e.g. goat milk, sheep milk,etc)?
The Vibrant Wellness Dairy Zoomer measures antibodies to peptides specific to cow milk only.
Different mammalian species will have different peptide/protein make up as they are genetically different species and proteins are derived from genes.
However, there is scientific uncertainty about cross-reactivity among mammalian milks. A provider needs to use clinical discretion and interpret a patient’s Dairy Zoomer results in context with history/symptoms and risk for reaction with other mammalian milks on an individualized basis.
Please note that Vibrant does offer protein-level food sensitivity testing specifically for GoatMilk (Food Sensitivity Profile I) and for Sheep Milk and Buffalo Milk (Food Sensitivity Profile II).
Dairy Sensitivity and Autoimmunity: What’s the Connection? https://vibrantwellnessblog.wordpress.com/2018/06/07/dairy-sensitivity-and-autoimmunity-whats-the-connection/
Are You Dairy Sensitive or Lactose Intolerant? What’s the Difference? https://vibrantwellnessblog.wordpress.com/2018/04/18/are-you-dairy-sensitive-or-lactose-intolerant-whats-the-difference/
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