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Methylation Panel
A health analytics tool for the detection of genetic polymorphisms associated with cellular methylation cycles
- Methylation is a critical cellular process that aids humans in processing certain nutrients and molecules to support:
- Energy production
- Detoxification
- Metabolism
- DNA
- Neurotransmitters
- Hormones
- Proteins such as cells, muscle, and carriers in the bloodstream
- Key nutrients play a role in methylation, and, without optimal levels of these nutrients in the correct form, methylation can become impaired and dysfunctional, leading to illness, disease, and affecting your quality of life
- Methylation generally refers to several complex cycles of chemical processes that are occurring at all times in human cells and a variety of genes affect how well methylation cycles operate
- A genetic abnormality of one or more genes related to methylation can cause these methylation cycles to become dysfunctional and require customized nutritional, medicinal, and lifestyle interventions
- Methylation pathways have significant overlap with virtually all organ systems and metabolic functions in the human body, and, therefore, can have a wide range of impacts to health, energy, detoxification, emotional and psychological function, and cognition
- Vibrant’s Methylation panel creates a personalized roadmap to addressing your patient’s complex and unique genetic needs for nutrients and lifestyle changes associated with them
- Consider additional nutrient testing, such as the Vibrant Micronutrient 3.0 and testing to detect whether your patient is at increased risk for toxic burden and oxidative stress due to methylation abnormalities, such as the Vibrant Total Tox Burden bundle
- In addition to Vibrant Micronutrients 3.0 and the Total Tox Burden bundle, also consider ordering Vibrant Neurotransmitters to assess direct pathways which may be affected by methylation abnormalities in the nervous system
The Vibrant Methylation panel includes the following genetic SNPs (single nucleotide polymorphisms):
- MTHFR (677)
- MTHFR (1298)
- COMT rs4680 (Val158Met)
- COMT rs4633 (C/T)
- MTRR rs1801394 (A66G)
- MTRR rs162036 (A/G)
- MAT1A rs3851059
- SHMT1 rs1979277
- GNMT rs10948059
- BHMT rs3733890
- MTR rs1805087
- NOS3 rs1799983
- Additional nutrients:
- Homocysteine
- Folate
- Vitamin b12
Conditions and Symptoms Associated with Methylation Abnormalities Include:
- Hyperhomocysteinemia
- Cardiovascular disease
- Neurotransmitter imbalances
- Psychological and emotional disorders
- Increased oxidative stress
- Impaired detoxification/increased toxic burden
- Mood disorders
- Low energy or fatigue
- Neurodegenerative disorders
- Fibromyalgia
- Increased risk for cancer
When interpreting results, what does the “>” symbol signify? Example MTHFR 677 C>T?
For any gene that is Mendelian inherited, one allele is considered “wild type,” or normal (non-mutated), while a different allele is considered “mutant.” In genetic nomenclature, the “>” is used to signify which allele is wild. In the example of “MTHFR 677 C>T”, the C allele is wild/normal whereas T allele is mutated.
What do the terms homozygous and heterozygous mean in terms of these genetics?
The terms homozygous and heterozygous refer to the individual genotype or individual result and describe the extent of normalcy or mutation. There are three possible combinations for each gene:
1. Homozygous wild type (no mutation; 2 copies of the normal allele)
2. Heterozygous mutant (one copy of wild allele; one copy of mutated allele)
3. Homozygous mutant (2 copies of a mutated allele)
Do the genetics change once you make the recommended changes on the report?
No, genetics do not change, only expression of the genetics.
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