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Neural Zoomer Plus

An expanded test to detect 48 of the most common autoantibodies associated with neurological autoimmunity and cognitive decline

The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers very specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual’s reactivity to 48 neurological antigens, which may have connections to a variety of neurologically related diseases.

With a panel of 48 of the most well-studied neurological autoantibodies, the Neural ZoomerTM Plus is able to guide providers in treatment protocols by pinpointing the mechanisms behind disease progression and providing a roadmap to solutions and improved health outcomes in this challenging arena of disease.
The test also has optional additional genetic testing for the ApoE genotype, which has been shown to influence risk for certain neurological conditions.

The Vibrant Neural ZoomerTM Plus aims to reduce the prevalence of neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.

By including the Vibrant Neural ZoomerTM Plus in their arsenal of available autoimmune and neurological tests, healthcare providers can arm themselves with the most advanced and relevant test available to assess the presence and risk of neurological autoimmunity.

The Neural ZoomerTM Plus is also the comprehensive compilation of multiple research studies which have identified autoantibodies associated with a range of neurological disorders, enabling early risk detection and prevention of neurological degeneration.

The Vibrant Neural ZoomerTM includes a comprehensive set of autoimmune markers, from a single serum draw including:

Demyelination Antigens
Anti-Tubulin
Associated with alcoholic liver disease, demyelinating disease, Grave’s disease, Hashimoto’s thyroiditis, infectious agent exposure PANDAS/ANDAS/OCD, rheumatoid arthritis, and recent onset type 1 diabetes.
Anti-Myelin basic protein
Related to the risk for multiple sclerosis, autism, PANDAS/ANDAS/OCD, and systemic lupus erythematosus (SLE).
Anti-Myelin oligodendrocyte glycoprotein (MOG)
Found in various demyelinating diseases, including multiple sclerosis, neuromyelitis optica spectrum disorders (NMOSD), idiopathic optic neuritis (ON), acute disseminated encephalomyelitis (ADEM), multiphasic disseminated encephalomyelitis (MDEM), Devic’s disease, and tumefactive demyelinating disease.
Anti-Myelin proteolipid protein
A useful marker in patients with seronegative anti-myelin basic protein, the frequent marker in active multiple sclerosis and optic neuritis.
Anti-Neurofascin
Found mainly in combined central and peripheral demyelination (CCPD), a rare demyelinating condition affecting both CNS and peripheral nervous system (PNS) tissues, and also in chronic inflammatory demyelinating polyneuropathy (CIDP) and axonal injury in patients with multiple sclerosis (MS).
Anti-MAG
Anti-MAG peripheral neuropathy is a very rare disease caused by anti-MAG antibodies that destroy MAG protein leading to disruptions of normal myelin production and healthy peripheral nerve activity.
Blood Brain Barrier Disruption
Anti-s100b
Blood brain barrier integrity breach and sub-concussive episodes lead to the production of this antibody. Extravasated s100B may trigger a pathologic autoimmune reaction linking systemic and CNS immune responses.
Anti-Glial fibrillary acidic protein
Anti-GFAP is produced when the protein enters the bloodstream after a rupture of the blood brain barrier, thus serves as a blood based diagnostic marker of brain injury.
Anti-Microglia
Indicate a destruction of the blood brain barrier and are found to play a role in tissue destruction of Alzheimer’s disease.
Anti-Glucose regulated protein 78
Glucose-regulated protein 78–targeted antibodies could instigate bloodbrain barrier breakdown and development of hallmark anti–aquaporin-4 autoantibody pathology.
Optical and Autonomic Nervous System Disorders
Anti-Neuron specific enolase
Antibodies against neuron specific enolase are found in patients with optical neuropathies.
Anti-Aquaporin 4
AQP4 IgG is involved in the development of neuromyelitis optica and revolutionized the understanding of the disease. Anti-Aquaporin4 antibodies have also been shown in patients with peripheral demyelination.
Anti-Recoverin
One of the key components of antibody disorders of the CNS. They have also been shown to be associated with retinopathy which is characterized by impaired vision and photosensitivity.
Anti-CV2
Seen in autoimmune paraneoplastic autonomic neuropathy and mixed axonal and demyelinating peripheral neuropathy
Peripheral Neuropathy
Anti-GM1
Associated with multi-focal motor neuropathy and lower motor neuropathy, characterized by muscle weakness and atrophy
Anti-GM2
A potential peripheral nerve antigen for neuropathy-associated autoantibodies
Anti-Hu
The most frequent manifestation of sensory neuropathy with frequent autonomic involvement
Anti-Ri
Can be detected in patients with the paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, gynecological cancers, and small cell lung cancer.
Anti-Amphiphysin
Often found in the serum of patients with stiff-person syndrome
Neuromuscular disorders
Anti-Acetylcholine receptors
Found in myasthenia gravis disease which destroys the receptor function, leading to a neuromuscular transmission defect, which then causes hypofunction, fatigue, and inflammation of skeletal muscles and produces serum antibodies against muscle antigens
Anti-Muscle specific kinase
An important marker in patients without anti-acetylcholine receptor antibodies in myasthenia gravis disease
Anti-Voltage gated calcium channels
Responsible for Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune disorder of the neuromuscular junction
Anti-Voltage gated potassium channels
Downregulate the potassium channels expressed on the peripheral nerve terminal leading to nerve hyperexcitability
Anti-Titin
Present in 70–90% of thymoma autoimmune myasthenia gravis (MG) patients, and in approximately 50% of late-onset acetylcholine-MG patients without thymoma
Brain Autoimmunity
Anti-Purkinje cell
Autoimmunity to a class of GABAergic neurons located in the cerebellum, which can produce abnormalities and decline in gross motor functions
Anti-Yo
Suggest that a patient with neurologic symptoms has a paraneoplastic syndrome. In addition, their presence also often suggests the nature of the underlying tumor.
Anti-Amyloid beta (25-35)
Levels of autoantibodies reacting with oligomers of the short, neurotoxic fragment Aβ (25-35) are significantly higher in AD patients than in healthy controls
Anti-Amyloid beta (1-42)
A signature marker in Alzheimer’s disease
Anti-RAGE peptide
Found in Alzheimer’s disease patients, and particularly higher in AD patients with diabetes
Anti-Tau
Found in the neurofibrillary tangles in brains of individuals who have Alzheimer’s disease
Anti-Glutamate
Found in epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren’s syndrome, schizophrenia, mania or stroke
Anti-Dopamine
Associated with movement disorders characterized by parkinsonism, dystonia, and Sydenham chorea
Anti-Hydroxytryptamine
Found mainly in autoimmune encephalitis
Anti-Alpha-synuclein
Mainly elevated in Parkinson’s disease and Alzheimer’s disease
Anti-α1 and β2 adrenergic receptors
Found mainly in patients with different dementia forms such as unclassified, Lewy body, vascular, and Alzheimer’s dementia
Anti-Endothelin A receptor
Found in vascular dementia
Brain Inflammation
Anti-NMDA receptor
Found in anti-NMDA receptor encephalitis
Anti-AMPA receptor
May play a role in Alzheimer’s disease, characterized by decreased AMPA activation and synapse loss
Anti-Dopamine receptors
Associated with Parkinson’s disease and other disorders of low dopamine status
Anti-GABA receptors
Associated with temporal lobe epilepsy (TLE), Parkinson’s disease (PD) and Huntington’s disease (HD) and other neurodegenerative disorders that involve disruptions in gamma-amino butyric acid (GABA) signaling
Anti-Dipeptidyl aminopeptidase-like protein 6
Associated with encephalitis
Anti-Glycine receptor
Helpful in the diagnosis of patients with symptoms and signs that include ocular motor and other brainstem dysfunction, hyperekplexia, stiffness, rigidity, myoclonus and spasms
Anti-Neurexin 3
Associated with a severe but potentially treatable encephalitis in which the antibodies cause a decrease of neurexin-3α and alter synapse development
Anti-Contactin-associated protein-like 2
Diseases associated with CNTNAP2 include Pitt-Hopkins-Like Syndrome 1 and Autism 15
Anti-Leucine-rich glioma-inactivated protein 1
LGI1 antibody–associated encephalitis has increasingly been recognized as a primary autoimmune disorder
Anti-Ma
Present in men with testicular tumors and isolated or combined limbic encephalitis (LE), diencephalic encephalitis (DE), or brainstem encephalitis (BE)
Infections
Anti-HSV-1
HSV-1 has been reported to have a pathogenesis role in Herpes simplex encephalitis (HSE) and seropositivity to HSV-1 antibodies has been correlated with increased risk of Alzheimer’s disease
Anti-HSV-2
Herpes simplex encephalitis (HSE) is a disorder commonly associated with HSV-2. HSE due to HSV-2 may occur without meningitis features. Antibodies against HSV-2 have shown positive correlation in patients with symptoms of HSE.
Anti-EBV
Antibodies against the EBV nuclear antigen complex (EBNAc) and EBNA-1 have been correlated with increased risk of multiple sclerosis (MS).
Anti-CMV
Cytomegalovirus (CMV) infections have been reported frequently to be associated with Guillain–Barre syndrome (GBS). There is a potential for molecular mimicry between GM2 and antigens induced by CMV infection.
Anti-HHV-6
Human herpesvirus-6 (HHV-6) is frequently associated with neurologic diseases, including multiple sclerosis (MS), epilepsy, encephalitis, and febrile illness.
Anti-HHV-7
HHV-7 has been less frequently associated with CNS disease than HHV-6, but found to be associated with encephalitis, meningitis, and demyelinating conditions. Similar to HHV 6A, increased levels of HHV-7 were found in multiple brain regions in Alzheimer’s disease (AD) patients.
Anti-Streptococcal A
Anti-streptococcal A antibodies are shown to cross react with different brain proteins that could lead to neuropsychiatric symptoms including PANDAS characterized by pediatric obsessive-compulsive disorder (OCD) and tic disorder, and Sydenham Chorea.

Symptoms associated with autoimmunity in the nervous system include:

  • Cognitive decline
  • Memory loss
  • Ataxia
  • Balance problems
  • Neuropathy
  • Alzheimer’s disease
  • Multiple sclerosis
  • Encephalitis
  • Muscle spasms
  • Huntington’s disease
  • Epilepsy
  • Parkinson’s disease
  • Dementia
  • Myasthenia gravis
  • Muscle stiffness/rigidity
  • Optical decline
  • Neuromyelitis optica
  • History of concussion
  • Autism
  • PANDAS/ANDAS/OCD
  • Demyelinating diseases

Can I use the Neural ZoomerTM Plus in the pediatric population?

It is important to note that Vibrant Neural ZoomerTM Plus has been validated in the adult population only. While we encourage and utilize this test in pediatric patients, there is a potential for false negatives in this population, as the reference ranges are established for adults.

A child’s immune system develops over time. They may not have “mature enough” immunoglobulins to mount a significant antibody response. Pediatric reference ranges for total immunoglobulin IgA, IgG, and IgM are much lower than adult reference ranges. Positive/reactive antigens on a pediatric test does indicate sensitivity, but a non-reactive test in the pediatric population could potentially be a false negative. In other words, there is a possibility that the Neural ZoomerTM Plus test may not discover a child’s immune response to those neurological antigens tested. It is important to assess a pediatrics baseline immunoglobulin response by measuring total immunoglobulins. Total IgG and total IgA are available on the Vibrant Wheat ZoomerTM.

How are reference ranges for the Vibrant Neural ZoomerTM Plus determined?

Vibrant has given a numerical value to quantify the antibodies measured by chemiluminescent signal of our microchip. The determination of the positive cutoff is by 97.5 percentile of 192 normal healthy controls. If you are above 97.5 percentile, you are considered positive. If 5% below cutoff (92.5-97.5 percentile), results are borderline. Less than 92.5 percentile, results are negative.

Should I do this test if I have had a concussion previously?

Yes! Post-concussion or traumatic brain injury (TBI) is a good reason to run this test. The Vibrant Neural ZoomerTM Plus measures markers of blood brain barrier permeability that are associated with disruption to the blood brain barrier (BBB), which can often occur after concussion or TBI. The Neural ZoomerTM Plus can show an increase in anti-neuron specific enolase antibodies, which are associated with optical neuropathies or traumatic brain injury (TBI).

When should I run the Neural ZoomerTM on a patient?

Anyone with symptoms of autoimmunity in the nervous system, such as neuropathic pain, MS, ataxia, brain fog, memory loss, etc, would benefit from the Neural ZoomerTM Plus. Because many of these conditions are related to celiac, and wheat and gluten enteropathies, it is best run after a Wheat ZoomerTM to check for intestinal permeability as well celiac and wheat/gluten sensitivity.

What is the difference between the Neural Zoomer and the Neural Zoomer Plus?

Below is a comparison table which includes antibodies tested on each test:

Neural Zoomer

Demyelination Antigens

  • Anti-Tubulin
  • Anti-Myelin basic protein

Blood Brain Barrier Disruption

  • Anti-s100b

Optical and Autonomic nervous system disorder

  • Anti-Neuron specific enolase

Peripheral Neuropathy

  • Anti-GM1
  • Anti-GM2
Neuromuscular disorders

Brain Autoimmunity

  • Anti- HSV1
  • Anti-Cerebellum
  • Anti- Purkinje cell
Brain Inflammation

Neural Genetics (optional add-on)

  • Apolipoprotein E
Infections

Neural Zoomer Plus

Demyelination Antigens

  • Anti-Tubulin
  • Anti-Myelin basic protein
  • Anti-Myelin oligodendrocyte glycoprotein
  • Anti-Myelin proteolipid protein
  • Anti-MAG
  • Anti-Neurofascin

Blood Brain Barrier Disruption

  • Anti-s100b
  • Anti-Glial fibrillary acidic protein
  • Anti-Microglia
  • Anti-Glucose regulated protein 78

Optical and Autonomic nervous system disorder

  • Anti-Neuron specific enolase
  • Anti-Aquaporin4
  • Anti-Recoverin
  • Anti-CV2

Peripheral Neuropathy

  • Anti-GM1
  • Anti-GM2
  • Anti-Hu
  • Anti-Ri
  • Anti-Amphiphysin

Neuromuscular disorders

  • Anti-Acetylcholine receptors
  • Anti-Muscle specific kinase
  • Anti-Voltage gated calcium channels (Anti-VGCC)
  • Anti-Voltage gated potassium channels
  • Anti-Titin

Brain Autoimmunity

  • Anti- HSV1
  • Anti-Cerebellum
  • Anti- Purkinje cell
  • Anti-Yo
  • Anti-Amyloid beta (25-35)
  • Anti-Amyloid beta
  • Anti-RAGE peptide
  • Anti-Tau
  • Anti-Glutamate
  • Anti-Dopamine
  • Anti-Alpha-synuclein
  • Anti-α1 and β2 adrenergic receptors
  • Anti-Endothelin A receptor
  • Anti-Hydroxytryptamine(Anti-5-HT)

Brain Inflammation

  • Anti-NMDA receptor
  • Anti-AMPA receptor
  • Anti-Dopamine receptors
  • Anti-GABA receptors
  • Anti-Glycine receptor
  • Anti-Dipeptidyl aminopeptidase like protein 6
  • Anti-Neurexin 3
  • Anti-Ma
  • Anti-Contactin-Associated Protein-like 2 Antibodies (CNTNAP2)
  • Anti-Leucine-rich glioma-inactivated protein 1 (Anti-LGI1)

Neural Genetics(optional add-on)

  • Apolipoprotein E

Infections

  • Anti-HSV-1
  • Anti-HSV-2
  • Anti-EBV
  • Anti-CMV
  • Anti-HHV-6
  • Anti-HHV-7
  • Anti-Streptococcal A

Recommended Tests to Consider

Wheat Zoomer
Gut Zoomer
Lectin Zoomer

Regulatory Statement

The general wellness test intended uses relate to sustaining or offering general improvement to functions associated with a general state of health while making reference to diseases or conditions. This test has been laboratory developed and its performance characteristics determined by Vibrant America LLC, a CLIA-certified laboratory performing the test. The test has not been cleared or approved by the U.S. Food and Drug Administration (FDA). Although FDA does not currently clear or approve laboratory-developed tests in the U.S., certification of the laboratory is required under CLIA to ensure the quality and validity of the tests.